Circulating Progenitor Cells

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Circulating progenitor cells: search for an identity.

Originally, the blood was viewed as a relatively simple tissue that was composed of plasma and a few subsets of immune, inflammatory, and erythrocytic cells. When Cohnheim published in 1867 his finding that “all cells come from the bloodstream and therefore . . . from the bone marrow,” this outstanding scientist of the nineteenth century could not anticipate the broad and far-reaching implicati...

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Circulating hematopoietic progenitor cells in runners.

Because endurance exercise causes release of mediators and growth factors active on the bone marrow, we asked whether it might affect circulating hematopoietic progenitor cells (HPCs) in amateur runners [n = 16, age: 41.8 +/- 13.5 (SD) yr, training: 93.8 +/- 31.8 km/wk] compared with sedentary controls (n = 9, age: 39.4 +/- 10.2 yr). HPCs, plasma cortisol, interleukin (IL)-6, granulocyte colony...

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Sex Differences in Circulating Progenitor Cells

BACKGROUND Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. Whether biologic sex and sex hormones influence PC numbers remains a subject of controversy. We sought to determine sex differences in circulating PCs in both healthy persons and patients with coronary artery disease,...

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Circulating endothelial progenitor cells exhibit diurnal variation.

Endothelial progenitor cells (EPCs) are circulating bone marrow–derived mononuclear cells that have the potential to promote postnatal neovascularization and endothelial repair.1 Reduced numbers of EPCs have been demonstrated in patients with coronary artery disease (CAD) and those with cardiac risk factors including smoking, hyperlipidemia, hypertension, diabetes mellitus, and increasing age.2...

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Circulating Endothelial Progenitor Cells in Cerebrovascular Disease

Stroke is associated with high disability and mortality burdens worldwide, but there are few effective and widely available therapies. There is therefore a need to develop treatments that promote the repair and regeneration of ischemic brain tissue. In this regard, a population of adult stem cells-called endothelial progenitor cells (EPCs)-has been identified in peripheral blood that could prov...

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ژورنال

عنوان ژورنال: Circulation

سال: 2004

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.0000148679.30170.78